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Introducción. La alergia a proteínas de leche de vaca (APLV) constituye la alergia alimentaria más frecuente en menores de un año. Es el resultado de una respuesta inapropiada del sistema inmune (mediada por IgE, no mediada por IgE o de naturaleza mixta) frente a las proteínas de leche de vaca (PLV) 1,2.